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NAYA Therapeutics – Pioneering Precision Therapeutics for Liver Cancer

NAYA Therapeutics

Naya Therapeutics is a US-based biotech developing NK cell engagers and targeted alpha radiopharmaceuticals to treat hepatocellular carcinoma and other solid tumors.

NAYA Tx: Episode Overview

Check out our episode overview to see how NAYA Therapeutics is harnessing NK cell engagers and Astatine-211 radiopharmaceuticals to address the urgent unmet need in liver cancer.

Episode Highlights: Featuring CEO & Founder Daniel Teper & Professor Yaron Ilan

Introduction to NAYA Therapeutics

HCC Is A Desperate Unmet Medical Need

NK cells & GPC3 - Perfect for Liver Cancer Therapy

The Liver Likes NK Cells. NK Cells Like The Liver.

If Astatine is SO RARE, how do you ensure supply?

Neobe Therapeutics: An Introduction

GPC3 for HCC

Solid tumors build thick barriers that prevent therapeutic entry.

The Problem & Opportunity

THE reason we need a multigenic approach to overcome the TME.

Shortcomings of Current Solutions

Neobe uses genetically engineered bacteria to “soften up” solid tumors…

Neobe’s Solution

How is Neobe’s Approach Different From Similar Companies?

Differentiation

B2B Brief: NAYA Therapeutics

Overview

Naya Therapeutics focuses on patients with hepatocellular carcinoma (HCC) who fail to respond to checkpoint inhibitors or chemotherapy. The company is advancing a dual-modality strategy: NK cell engagers to restore innate immune function and alpha radiopharmaceuticals to eradicate residual disease.

This approach directly addresses the limitations of current HCC therapies, where response rates remain below 30%.

Leadership

Led by Daniel Teper, PharmD, MBA (Chairman & CEO), Naya’s leadership team brings significant experience in oncology innovation, financing, and commercialization. Executives include Michael G. King (EVP), Raquel Cabo (COO), Lyn Falconio (CCO), Dan Chiche, MD (CMO), Vidisha Mohad, PhD (Head of Product Development), and Ravi Kiron, PhD, MBA (CBO). The board and advisors feature veterans from Sanofi, Amgen, Pfizer, and venture firms .

Naya’s clinical program is guided by Prof. Yaron Ilan (featured in this episode), a hepatology leader and former President of the Israeli Liver Association, with decades of experience in liver cancer and chronic liver disease.

Scientific Overview

Naya’s NK cell engager platform leverages NKp46 activation to restore functionality in exhausted NK cells and redirect them against GPC3-expressing tumors, the dominant biomarker in HCC.

In parallel, its radiopharmaceutical platform employs antibody fragments conjugated with astatine-211 (At-211), an alpha-emitter with a short half-life, simple decay chain, and covalent binding chemistry, enabling high tumor penetration and outpatient administration.

Clinical Plans & Potential Impact

The lead NK cell engager will enter Phase 1 clinical testing in checkpoint inhibitor non-responders in HCC.

The radiopharmaceutical program aims to establish proof-of-concept in minimal residual disease settings, with potential expansion to other solid tumors.

Together, the two modalities are designed to raise HCC response rates well above current standards, with global relevance given rising HCC incidence.

Due Diligence

The Good

This is different:

Unlike T-cell therapies, which risk collateral damage in cirrhotic livers, NK biology is naturally aligned with liver immunity. The liver harbors a high proportion of NK and NKT cells, making them the frontline defense against malignant transformation.

Naya’s unique patient fit:

Most HCC patients present with advanced disease on a background of cirrhosis or failing livers, where treatment tolerance is low and systemic toxicity is often lethal. Naya’s therapeutics – precise, NK-driven cytotoxicity and short-lived, clean-decay alpha therapy – are designed to minimize collateral liver injury while targeting residual disease.

Naya’s strategic advantage:

By tailoring therapies to the unique physiology and vulnerability of late-stage liver patients, Naya occupies a niche where checkpoint inhibitors and T-cell therapies often fail due to poor response rates or unacceptable toxicity.

The Risks

Therapeutic:

No clinical proof yet for NAYA’s strategy of NK cell engagers and ²¹¹At radiopharmaceuticals in HCC; efficacy and safety remain to be demonstrated.

Logistical:

Manufacturing bispecifics is complex; ²¹¹At’s short half-life complicates supply/distribution; recruiting post–checkpoint inhibitor HCC patients is challenging.

Regulatory:

First-in-class modalities face uncertain FDA/EMA pathways; heightened CMC/dosimetry scrutiny; reimbursement risks if costs outweigh incremental benefit over existing standards.

The Competition

NK cell engagers:

Innate Pharma, Dragonfly, and Affimed are developing NK engager platforms, with most programs focused on hematologic malignancies or using CD16 as the engager. Naya differentiates by targeting NKp46, a receptor with stronger and more durable activation, particularly relevant in solid tumors such as HCC.

Targeted alpha therapies (TATs):

Bayer and RayzeBio/BMS are advancing GPC3–Actinium-225 radiopharmaceuticals for HCC, while Novartis and AstraZeneca have made large bets in PSMA and other alpha radioligands. Naya’s advantage is the use of astatine-211, which has a short half-life, a clean single decay path, and outpatient feasibility, addressing many limitations of actinium and lutetium approaches.

But this company is different:

By focusing squarely on HCC biology and aligning modality to setting — NKp46 engagers for refractory tumors and At-211 radiopharma for micro-metastatic disease — Naya avoids the “one-size-fits-all” strategy and positions itself in niches where existing competitors are less well-suited.

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